Related Experiment Video
Updated: Mar 13, 2026

Culturing Primary Rat Inner Medullary Collecting Duct Cells
Published on: June 21, 2013
Outside the mainstream: novel collecting duct proteins regulating water balance
Shamma S Rahman1, Erika I Boesen2
1Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
Abstract:
Body water balance is critical to survival and, therefore, very tightly regulated by the hypothalamus and kidney. A key mechanism involved in this process, the arginine vasopressin-mediated phosphorylation and apical membrane insertion of aquaporin 2 in the collecting duct, has been extensively studied; however, with the increased availability of conditional knockout animals, several novel collecting duct proteins have recently been implicated in water homeostasis. In this Mini-Review, we briefly discuss these novel proteins and their roles in the regulation of water homeostasis.
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