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Related Experiment Videos

Invariant death.

Steven A Frank1

  • 1Department of Ecology and Evolutionary Biology, University of California, Irvine, CA, 92697-2525, USA.

F1000Research
|October 28, 2016
PubMed
Summary
This summary is machine-generated.

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Environmental and genetic changes affect death timing in nematodes and cancer, respectively. These changes adhere to a universal geometric constraint, explaining variations in death rates through a generalized Gompertz law.

Area of Science:

  • Biophysics
  • Mathematical Biology
  • Geroscience

Background:

  • Environmental or physiological factors alter mortality timing in nematodes.
  • Genetic factors modify mortality timing in human cancers.
  • These alterations follow predictable geometric patterns.

Purpose of the Study:

  • To investigate the fundamental geometric constraints governing death's scaling and curvature.
  • To demonstrate how these constraints arise from extensions to theories of randomness, invariance, and scale.
  • To explain perturbation-induced changes in mortality timing via a generalized Gompertz law.

Main Methods:

  • Theoretical analysis extending randomness, invariance, and scale theories.
  • Derivation of a generalized Gompertz law from fundamental geometric principles.
Keywords:
Gompertz distributionMortalitycancernematodesprobability theory

Related Experiment Videos

  • Analysis of how geometric constraints influence mortality scaling and curvature.

    • Main Results:

    • A fundamental geometric framework for death's scaling and curvature was identified.
    • This framework leads to a generalized Gompertz law.
    • The invariant geometry explains how perturbations stretch or bend mortality time.

    Conclusions:

    • Mortality timing is governed by universal laws and specific biological processes.
    • Invariant geometric constraints dictate the response of death's scaling to perturbations.
    • Variability in death rates results from the interplay between universal laws and biological specifics.