Related Experiment Video
Updated: Mar 13, 2026
11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
13.5K
Operational and Clinical Strategies to Address Drug Cost Containment in the Acute Care Setting
Karen J McConnell1, Oscar E Guzman1, Nisha Pherwani1
1Innovative Delivery Solutions, Cardinal Health, Houston, Texas.
Pharmacotherapy
|November 3, 2016
Summary
Hospitals can reduce drug expenses through operational and clinical strategies. Implementing an interdisciplinary team approach systematically reviews drug costs and guides cost-saving initiatives for better financial management.
Area of Science:
- Health economics
- Hospital pharmacy management
- Clinical pharmacology
Background:
- Hospitals face increasing financial pressures, with pharmacies often tasked with managing drug costs.
- Cost-containment strategies require pharmacy-directed activities and interdisciplinary collaboration.
Purpose of the Study:
- To outline clinical and operational strategies for achieving drug cost savings in hospitals.
- To provide a framework for systematic drug cost review and management.
Main Methods:
- A comprehensive literature search of the PubMed database was conducted up to July 2016.
- Inclusion criteria encompassed prospective/retrospective studies, guidelines, consensus statements, and reviews published in English.
Main Results:
- Review of 937 abstracts revealed diverse strategies for drug cost reduction in acute care settings.
- Operational strategies involve contracting, purchasing, and inventory management.
- Clinical strategies include formulary management, use criteria, and dose optimization by clinical pharmacists.
Conclusions:
- Acute care hospitals can effectively lower overall drug costs using a combination of operational and clinical strategies.
- A systematic, stepwise approach is recommended for ongoing review and management of drug expenditures.
Related Concept Videos
01:26Pharmaceutical Poisoning: Treatment Strategies
109
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
109
01:26Pharmaceutical Poisoning: Potential Scenarios
53
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
53
01:29Issues And Trends In Healthcare Delivery System
6.3K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
6.3K
01:26Methods Of Healthcare Delivery System
4.2K
At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
4.2K
00:59Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
384
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
384
01:22Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
235
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
235