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The Effect of Intravenous Acetaminophen on Patient Outcomes within a Large Integrated Delivery Network
Henry P Mattern1, James C Reichert1, Karen J McConnell1
1Catholic Health Initiatives, Englewood, Colorado.
Pharmacotherapy
|January 30, 2020
Summary
Intravenous acetaminophen did not improve patient outcomes like length of stay or narcotic use. Clinicians should reconsider its routine administration based on this evidence.
Area of Science:
- Pharmacology
- Clinical Medicine
- Health Services Research
Background:
- Intravenous acetaminophen is used for pain management.
- Its impact on key patient outcomes requires further evaluation.
Purpose of the Study:
- To assess the effect of intravenous acetaminophen on patient outcomes.
- Investigate its association with length of stay, narcotic use, and readmission rates.
Main Methods:
- Retrospective observational analysis of 54,742 patients across 19 hospitals.
- Compared outcomes between patients receiving and not receiving intravenous acetaminophen.
- Analyzed total length of stay, ICU length of stay, total narcotic use (MME), discharge narcotic prescription likelihood, and 30-day readmission rates for five procedures and a combined group.
Main Results:
- No significant improvement in total length of stay, ICU length of stay, or 30-day readmission rates was observed with intravenous acetaminophen.
- The control group (no intravenous acetaminophen) showed shorter total length of stay in the combined population.
- The control group also had lower total narcotic use and reduced likelihood of discharge narcotic prescriptions in specific populations (cesarean section, CABG, combined).
Conclusions:
- Intravenous acetaminophen was not associated with improved patient outcomes.
- Findings suggest clinicians may reconsider the routine use of intravenous acetaminophen.
- Further research may be needed to identify specific patient groups that could benefit.
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