Gold nanoprism-nanorod face off: comparing the heating efficiency, cellular internalization and thermoablation
Gabriel Alfranca1,2, Álvaro Artiga2, Grazyna Stepien3
1Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film & Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 200240-Shanghai, PR China.
Aim:
This work compares the synthesis, heating capability, cellular internalization and thermoablation capacity of two different types of anisotropic gold nanoparticles: gold nanorods (NRs) and nanoprisms (NPrs).
Methods:
Both particles possess surface plasmon resonance absorption bands in the near-IR, and their heating efficiency upon irradiation with a continuous near-IR laser (1064 nm) was evaluated. The cellular internalization, location and toxicity of these PEG-stabilized NPrs and NRs were then assessed in the Vero cell line by transmission electron microscopy and inductively coupled plasma mass spectrometry analysis, and their ability to induce cell death upon laser irradiation was then evaluated and compared.
Results & Conclusion:
Although both nanoparticles are highly efficient photothermal converters, NRs possessed a more efficient heating capability, yet the in vitro thermoablation studies clearly demonstrated that NPrs were more effective at inducing cell death through photothermal ablation due to their greater cellular internalization.
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