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Antiphospholipid arterial vasculopathy
D Alarcón-Segovia1, M H Cardiel, E Reyes
1Department of Immunology, Instituto Nacional de la Nutrición Salvador Zubirán, México, DF.
The Journal of Rheumatology
|June 1, 1989
Summary
Three young patients experienced limb arterial occlusions due to antiphospholipid antibodies (APLA). This study suggests a new APLA-related vasculopathy potentially triggered by vasculitis, presenting with arterial narrowing and proliferation.
Area of Science:
- Vascular Biology
- Immunology
- Rheumatology
Background:
- Antiphospholipid antibodies (APLA) are associated with thrombosis.
- Systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS) are key conditions linked to APLA.
Observation:
- Three young patients presented with limb arterial occlusions necessitating amputation.
- All patients tested positive for antiphospholipid antibodies (APLA).
Findings:
- Angiograms revealed progressive arterial lumen narrowing.
- Histopathology showed significant intimal and medial proliferation, with adventitial thickening.
- Mononuclear cell infiltrates were observed in large arteries of early amputees.
- Leukocytoclastic vasculitis was present in skin and/or muscle tissues.
Implications:
- This suggests a novel APLA-associated vasculopathy.
- The condition may be triggered by vasculitis.
- Understanding this vasculopathy is crucial for managing APLA-related vascular complications.