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Updated: Mar 13, 2026

Angiogenesis in the Ischemic Rat Lung

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Lymphangiogenesis in rat asthma model.

Aigul Moldobaeva¹, John Jenkins¹, Qiong Zhong¹

¹Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224, USA.

|October 28, 2016

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Allergic asthma increases lung lymphatic vessels and enhances lymphatic endothelial cell function. These changes in lymphangiogenesis are linked to vascular endothelial growth factor receptor signaling.

Area of Science:

Pulmonary Medicine
Vascular Biology
Immunology

Background:

Bronchial angiogenesis is documented in asthma, but lung lymphangiogenesis remains understudied.
Asthma models provide insights into airway inflammation and remodeling.

Purpose of the Study:

To investigate changes in lung lymphatics during allergen-induced asthma.
To characterize the in vitro behavior of lung lymphatic endothelial cells from asthmatic rats.

Main Methods:

A rat model of house dust mite (HDM)-induced asthma was used.
Lung morphometry assessed lymphatic vessel changes.
In vitro studies analyzed proliferation, chemotaxis, and tube formation of isolated lymphatic endothelial cells.

Main Results:

Keywords:

Allergen Angiogenesis House dust mite Lung Lymphatic vessels

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Last Updated: Mar 13, 2026

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A 34% increase in lung lymphatic vessels was observed in asthmatic rats.
Lymphatic endothelial cells from sensitized lungs exhibited enhanced proliferation, chemotaxis, and tube formation.
These enhanced properties were retained in vitro and were VEGFR-dependent.

Conclusions:

Allergen sensitization induces significant changes in lung lymphatic endothelium.
The hyper-proliferative lymphangiogenic phenotype of lymphatic endothelial cells is maintained in vitro.
VEGFR downstream signaling plays a crucial role in asthma-related lymphangiogenesis.