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pMHC Multiplexing Strategy to Detect High Numbers of T Cell Responses in Parallel
Daisy Philips1, Marlous van den Braber1, Ton N Schumacher1
1Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, CX, 1066, The Netherlands.
Methods in Molecular Biology (Clifton, N.J.)
|October 28, 2016
Abstract:
The development of peptide loaded major histocompatibility complexes (MHC) conjugated to fluorochromes by Davis and colleagues 20 years ago provided a highly useful tool to identify and characterize antigen-specific T cells. In this chapter we describe a multiplexing strategy that allows detection of high numbers of T cell responses in parallel.
