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Abnormal lipid metabolism in adjuvant arthritic rats
Y Yamaguchi1, Y Tanaka, K Yamada
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
Japanese Journal of Pharmacology
|August 1, 1989
Summary
Adjuvant arthritis in rats alters lipid metabolism, decreasing cholesterol and triglycerides before onset. Drug treatments normalized these changes, suggesting a link to immunopathology, not inflammation.
Area of Science:
- Biochemistry
- Immunology
- Pharmacology
Background:
- Adjuvant arthritis is a model for inflammatory joint disease.
- Lipid metabolism alterations are observed during inflammatory conditions.
Purpose of the Study:
- To investigate changes in lipid metabolism during adjuvant arthritis development in rats.
- To evaluate the effects of cyclophosphamide and indomethacin on these metabolic changes.
Main Methods:
- Induction of adjuvant arthritis in rats.
- Monitoring of serum lipid profiles (total cholesterol, HDL-cholesterol, triglycerides, phospholipids) and lecithin-cholesterol acyltransferase activity.
- Administration of cyclophosphamide and indomethacin to assess their impact on arthritis and lipid metabolism.
Main Results:
- Early decreases in serum total cholesterol, HDL-cholesterol, triglycerides, and lecithin-cholesterol acyltransferase activity were observed.
- Progressive arthritis led to increased serum total cholesterol, HDL-cholesterol, free-cholesterol, and lipid peroxide levels.
- Cyclophosphamide normalized lipid and enzyme alterations, while indomethacin primarily affected triglycerides, despite both drugs suppressing arthritis.
Conclusions:
- Abnormal lipid metabolism in adjuvant arthritis is linked to the immunopathologic response, not the inflammatory activity.
- Drug efficacy in normalizing lipid metabolism differs between immunosuppressive and anti-inflammatory agents.