Enhancing activity of anthranilic acid on adjuvant arthritis in rats and antibody formation in mice
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M Kunitomo1, Y Tanaka, K Yamada
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
Japanese Journal of Pharmacology
|August 1, 1989
Abstract:
Anthranilic acid (ANA), a metabolite of tryptophan, was examined for its immunopotentiating properties. Administration of ANA (12 mg/kg/day, p.o.) significantly enhanced the development of adjuvant arthritis in rats, although not in a dose-related manner. ANA tended to enhance adjuvant disease moderately suppressed by pretreatment with cyclophosphamide (CY), an immunosuppressive agent. ANA (3-30 mg/kg/day, p.o.) also caused a dose-related enhancement in the antibody formation to sheep erythrocytes (SRBC) in mice.