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Updated: Mar 13, 2026

Functional Imaging of Auditory Cortex in Adult Cats using High-field fMRI

Functional Imaging of Auditory Cortex in Adult Cats using High-field fMRI

Published on: February 19, 2014

Tonotopic maps in human auditory cortex using arterial spin labeling.

Anna Gardumi¹, Dimo Ivanov¹, Martin Havlicek¹

¹Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.

Human Brain Mapping

|October 30, 2016

Summary

This summary is machine-generated.

Cerebral blood flow (CBF) mapping using pseudo-continuous arterial spin labeling (pCASL) effectively maps auditory cortex tonotopy. Baseline CBF also serves as a novel marker for auditory cortex parcellation.

Keywords:

ASL CBF SWI fMRI primary auditory cortex quantitative perfusion tonotopy

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Mapping the After-effects of Theta Burst Stimulation on the Human Auditory Cortex with Functional Imaging

Mapping the After-effects of Theta Burst Stimulation on the Human Auditory Cortex with Functional Imaging

Published on: September 12, 2012

Area of Science:

Neuroimaging
Auditory Neuroscience
Functional Magnetic Resonance Imaging (fMRI)

Background:

The tonotopic organization of the human auditory cortex (AC) is established, but a complete functional parcellation is lacking.
Standard fMRI relies on the Blood Oxygen Level-Dependent (BOLD) signal, which may be influenced by venous bias.
Novel imaging techniques are needed to fully characterize AC functional organization.

Purpose of the Study:

To investigate the feasibility of using cerebral blood flow (CBF) via pseudo-continuous arterial spin labeling (pCASL) for mapping auditory cortex tonotopy and voice-selective regions.
To compare CBF-based tonotopy with traditional BOLD signal-based tonotopy.
To explore baseline CBF as a potential marker for AC parcellation and investigate BOLD signal's venous bias.

Main Methods:

Pseudo-continuous arterial spin labeling (pCASL) was employed to measure CBF for tonotopic mapping.
BOLD signal-based fMRI was used for comparison.
Susceptibility weighted imaging (SWI) was utilized to assess tissue specificity and potential venous contamination.

Main Results:

CBF-based tonotopy was successfully demonstrated and showed good agreement with BOLD-based tonotopy, despite lower contrast-to-noise ratio.
Quantitative perfusion mapping revealed high baseline CBF in a region corresponding to the primary auditory core, suggesting its utility for AC parcellation.
BOLD-only active voxels exhibited higher venous contamination compared to CBF-only active voxels.

Conclusions:

CBF-based fMRI, using pCASL, is a viable alternative to BOLD for studying auditory processing and functional AC organization.
Baseline CBF provides a novel, quantitative marker for delineating the primary auditory cortex.
CBF-based methods may offer advantages over BOLD by potentially reducing venous bias in functional mapping.