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Related Concept Videos

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

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Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
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Oxygen Delivering System I: Nasal Cannula and Face Mask01:26

Oxygen Delivering System I: Nasal Cannula and Face Mask

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The human body requires oxygen to function, and when the natural process of respiration is hindered, external devices, including the following, are needed to help deliver this vital gas.
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
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Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
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Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

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Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
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Administering Oxygen by Mask01:30

Administering Oxygen by Mask

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Administering Oxygen by Mask
Administering oxygen by mask is a common nursing intervention that provides supplemental oxygen to patients with respiratory distress or chronic lung conditions. This procedure involves delivering oxygen at a specified rate through a face mask connected to an oxygen source.
Equipment
The equipment necessary for this procedure includes:
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Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

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Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
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Related Experiment Video

Updated: Mar 13, 2026

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures
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Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures

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Oxygen delivery using engineered microparticles.

Raymond P Seekell1,2, Andrew T Lock1, Yifeng Peng1,2

  • 1Division of Basic Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115.

Proceedings of the National Academy of Sciences of the United States of America
|November 3, 2016
PubMed
Summary
This summary is machine-generated.

A new polymer-based oxygen delivery agent, polymer hollow microparticles (PHMs), can rapidly increase blood oxygen levels. These microparticles are safe, effective, and can be stored for extended periods.

Keywords:
colloidscore–shellhypoxemiamicroparticleoxygen

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Area of Science:

  • Biomaterials Science
  • Medical Devices
  • Respiratory Medicine

Background:

  • Continuous oxygen supply is critical for tissue viability.
  • Severe hypoxemia significantly increases mortality risk.
  • Rapid and effective treatments for hypoxemia are needed.

Purpose of the Study:

  • To develop a novel polymer-based intravascular oxygen delivery agent.
  • To characterize the oxygen-releasing capabilities and safety of this agent.

Main Methods:

  • Fabrication of polymer hollow microparticles (PHMs) with nanoporous shells.
  • Charging PHMs with oxygen gas.
  • In vitro and in vivo testing of oxygen release and efficacy.
  • Assessment of storage stability.

Main Results:

  • PHMs efficiently load and release oxygen in response to desaturated blood.
  • Oxygen release is diffusion-controlled.
  • PHMs deliver five times more oxygen per gram than red blood cells.
  • In vivo studies demonstrated safety and effectiveness.
  • PHMs remained stable after 2 months of room temperature storage.

Conclusions:

  • Polymer hollow microparticles represent a promising new strategy for intravascular oxygen delivery.
  • PHMs offer a high oxygen carrying capacity and controlled release.
  • The agent demonstrates potential for treating hypoxemia due to its efficacy, safety, and storage stability.