Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of urinary metabolite biomarkers of psychiatric disorders using two-sample Mendelian randomization.

BMC psychiatry·2026
Same author

Drug Repurposing Uncovers New Chemical Scaffolds as Potent Urease Inhibitors: A Comprehensive Computational Study.

International journal of molecular sciences·2026
Same author

Tough and Rapidly Relaxing Hydrogels Via Programmable Crosslink Kinetics.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Spatial variation of energy transport mechanisms within solar flare ribbons.

Nature astronomy·2026
Same author

Oligomerisation and stereoselective polymerisation of alkenes and alkynes using pyridyl-based Al(iii) catalysts.

Chemical science·2026
Same author

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

Journal of chemical information and modeling·2026
Same journal

Selective Degradation of Polyurethanes in Mixed Plastic Wastes via Ir-Catalyzed Hydrogenolysis.

Angewandte Chemie (International ed. in English)·2026
Same journal

Covalent Organic Framework Photocatalysts: Decoding Linkage Chemistry in Hydrogen Peroxide Synthesis From Air and Water.

Angewandte Chemie (International ed. in English)·2026
Same journal

Anomeric Amide Enabled Divergent Synthesis of Unsymmetrical Ureas, Carbamates, Thioesters, and Amides From Aldehydes.

Angewandte Chemie (International ed. in English)·2026
Same journal

Anisotropic Magneto-Chiral Dichroism in Lanthanide Complexes.

Angewandte Chemie (International ed. in English)·2026
Same journal

Engineering LE-CT State Synergy in Aminoboranes for Single Molecule White Light Emission and Dual-Mode Chiroptical/Phosphorescence Output.

Angewandte Chemie (International ed. in English)·2026
Same journal

Editable Hydrogen Bond Network Within the Electric Double Layer for CO<sub>2</sub> Reduction.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

Free-form Light Actuators &#8212; Fabrication and Control of Actuation in Microscopic Scale
08:17

Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale

Published on: May 25, 2016

9.7K

A Dynamic and Responsive Host in Action: Light-Controlled Molecular Encapsulation.

Seán T J Ryan1, Jesús Del Barrio2,1, Reynier Suardíaz3

  • 1Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

Angewandte Chemie (International Ed. in English)
|October 30, 2016
PubMed
Summary
This summary is machine-generated.

Researchers designed a light-responsive molecular box, oAzoBox4+, that can capture and release small molecules. Photoisomerization of azobenzene units changes the box

Keywords:
host-guest systemshydrogen bondsmacrocyclesphotochemistrysupramolecular chemistry

More Related Videos

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
10:10

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags

Published on: January 17, 2019

11.5K
Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

1.8K

Related Experiment Videos

Last Updated: Mar 13, 2026

Free-form Light Actuators &#8212; Fabrication and Control of Actuation in Microscopic Scale
08:17

Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale

Published on: May 25, 2016

9.7K
Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
10:10

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags

Published on: January 17, 2019

11.5K
Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

1.8K

Area of Science:

  • Supramolecular Chemistry
  • Photochemistry
  • Molecular Recognition

Background:

  • Azobenzene derivatives are known for their photoresponsive E↔Z isomerization.
  • Supramolecular chemistry utilizes non-covalent interactions for molecular assembly.
  • Macrocyclic hosts can selectively bind guest molecules.

Purpose of the Study:

  • To design and synthesize a photochromic molecular box capable of light-controlled guest sequestration.
  • To investigate the use of azobenzene photoisomerization for dynamic cavity size modulation.
  • To explore supramolecular recognition of small molecules using hydrogen-bonding motifs.

Main Methods:

  • Rational design and synthesis of the oAzoBox4+ macrocycle.
  • Utilizing E↔Z photoisomerization of incorporated azobenzene units upon light absorption.
  • Employing imidazolium groups as hydrogen-bond donors for guest binding.
  • Spectroscopic and binding studies to confirm guest sequestration and release in acetonitrile.

Main Results:

  • Successful synthesis of the oAzoBox4+ molecular box.
  • Demonstration of light-induced E→Z photoisomerization altering the macrocycle's cavity shape.
  • Evidence of selective sequestration of small molecule guests via hydrogen bonding.
  • Observation of guest expulsion from the cavity upon E→Z photoisomerization.

Conclusions:

  • The oAzoBox4+ molecular box effectively integrates photochromic and supramolecular functionalities.
  • Photoisomerization of azobenzene units provides a mechanism for light-controlled guest release.
  • This system offers a novel approach for light-switchable molecular recognition and sequestration.