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[Hepatogenic ulcer (various aspects of its pathogenesis)]
Klinicheskaia Meditsina
|June 1, 1989
Summary
Liver cirrhosis patients, particularly those with alcoholic or viral forms, have a high incidence of stomach ulcers. These ulcers often present without symptoms and are linked to reduced stomach acid and portal hypertension.
Area of Science:
- Gastroenterology
- Hepatology
- Internal Medicine
Background:
- Liver cirrhosis frequently leads to gastrointestinal complications.
- Hepatogenous ulcers are a known, yet often under-recognized, complication of liver cirrhosis.
- Portal hypertension is a significant factor influencing the severity of cirrhotic complications.
Purpose of the Study:
- To investigate the functional and morphological changes in the stomach and duodenum of liver cirrhosis patients.
- To determine the prevalence of hepatogenous ulcers in alcoholic and viral liver cirrhosis.
- To identify risk factors and diagnostic markers for gastrointestinal lesions in liver cirrhosis.
Main Methods:
- Studied 98 patients with liver cirrhosis.
- Assessed functional and morphological state of the stomach and duodenum.
- Utilized Doppler ultrasonography to evaluate portal blood flow.
Main Results:
- Hepatogenous ulcers found in 21.7% of alcoholic and 25% of viral liver cirrhosis patients.
- Ulcers occurred with reduced gastric acid production and were often asymptomatic.
- Gastric and duodenal affections were significantly more common in patients with pronounced portal hypertension.
Conclusions:
- Pronounced portal hypertension is a key indicator for increased risk of erosion-ulcerous lesions in liver cirrhosis.
- Doppler ultrasonography can identify patients at high risk.
- Regular endoscopic monitoring (2-3 times/year) is crucial for high-risk patients.