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Updated: Sep 19, 2025

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
[Development of conditions for determination of imidazole derivatives in the blood using chromatography-mass
S S Kataev1, O N Dvorskaya2, A V Vasilenko3
1Perm Regional Center of Hygiene and Epidemiology, Perm, Russia.
Abstract:
The problem of clonidine, moxonidine, tizanidine determination in forensic studies of biological objects remains due to low therapeutic and toxic concentrations in biological material, that creates certain difficulties in detecting the use of these substances. The study objective is to develop chromato-mass-spectrometry conditions for imidazole derivatives determination in the blood for purposes of forensic chemical and chemical toxicological analysis. The conditions for reliable clonidine, moxonidine, tizanidine identification in the blood using solid-phase extraction and gas chromatography with mass-spectrometry detection are selected. Gas chromatographic and mass spectrometric characteristics of clonidine, moxonidine, tizanidine derivatives which can be used for the purposes of forensic chemical and chemical toxicological analysis were studied.
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