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Published on: January 28, 2020
Comparison of hemorheological changes in patients after acute coronary events, intervention and ambulatory
Andras Toth1,2, Barbara Sandor1, Zsolt Marton1
11st Department of Medicine, Medical School, University of Pecs, Pecs, Hungary.
Insights
Cardiovascular rehabilitation training programs (CRP) improve hemorheological parameters (HPs) in patients with ischemic heart disease (IHD). CRP participation reverses hemorheological deterioration, unlike non-participation.
Area of Science:
- Cardiology
- Hematology
- Exercise Physiology
Background:
- Altered hemorheological parameters (HPs) are linked to ischemic heart disease (IHD) severity and myocardial ischemia pathogenesis.
- Lack of regular exercise is a significant cardiovascular risk factor.
- Cardiovascular rehabilitation training programs (CRP) are recommended for IHD treatment and event prevention.
Purpose of the Study:
- To evaluate the hemorheological effects of CRP in patients post-coronary event or intervention.
- To compare hemorheological changes in CRP participants versus non-participants.
Main Methods:
- Prospective evaluation of data from four studies (three non-CRP, one CRP-participating).
- Analysis of hemorheological parameters including hematocrit (Hct), plasma and whole blood viscosity (WBV), Hct/WBV ratio, and red blood cell aggregation.
- Follow-up duration of 6-12 months.
Main Results:
- Non-CRP groups showed significant increases in Hct, plasma and WBV, and Hct/WBV ratio.
- The CRP group exhibited significant decreases in these parameters.
- Red blood cell aggregation decreased substantially more in the CRP group.
Conclusions:
- CRP demonstrates beneficial hemorheological effects in IHD patients.
- CRP can reverse hemorheological deterioration following coronary events or interventions.
Abstract:
During the past decades, our group have investigated the hemorheological parameters (HPs) of more than 1,000 patients with various forms of ischemic heart disease (IHD). Our data indicate that HPs are altered in patients with IHD and the extent of the alterations is in good correlation with the clinical severity of the disease. Our findings have also proven that HPs play a critical role in the pathogenesis of myocardial ischemia.The lack of regular exercise is an important cardiovascular risk factor. Regular physical activity - as part of the cardiovascular rehabilitation training program (CRP) - is recommended for the treatment of IHD and the prevention of first or further cardiovascular events. To estimate the beneficial hemorheological effects of CRP, compared to patients after a coronary event or intervention and not participating in CRP, the data of four of our prospective studies (three non-CRP and one CRP-participating) were evaluated.Hematocrit (Hct), plasma and whole blood viscosity (WBV), Hct/WBV ratio significantly (p < 0.05) increased in the non-CRP groups during the 6-12 months follow-up, while in the CRP group they significantly decreased (p < 0.05). Red blood cell aggregation decreased in a much greater manner in the CRP group.Our results indicate that CRP has beneficial hemorheological effects and is able to reverse the deterioration of HPs after coronary events or intervention.
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