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Updated: Jul 14, 2026
Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
Human immunodeficiency virus associated plasmablastic lymphoma: A case report.
Dinkar Desai1, Siddharth Pandit1, Shiny Jasphin2
1Department of Oral and Maxillofacial Pathology and Microbiology, AJ Institute of Dental Sciences, Manipal, Karnataka, India.
Plasmablastic lymphoma, a rare oral cancer, often affects HIV-positive individuals. Diagnosis requires immunohistochemistry to distinguish it from other lymphomas.
Area of Science:
- Oncology
- Pathology
- Immunology
Background:
- Non-Hodgkin's lymphoma (NHL) is a common oral malignancy.
- Plasmablastic lymphoma (PBL) is a rare, aggressive NHL subtype, primarily affecting HIV-infected individuals.
- PBL accounts for about 2.6% of all NHL cases.
Observation:
- This study details a case of PBL in a 50-year-old, HIV-infected female.
- The lymphoma presented as a diffuse oral lesion.
- Differentiating PBL from other NHLs is diagnostically challenging.
Findings:
- Histopathological examination and immunophenotyping confirmed the PBL diagnosis.
- Immunohistochemistry is crucial for accurate PBL diagnosis.
- The case highlights PBL presentation in a specific demographic.
Implications:
- Accurate diagnosis of PBL is critical for appropriate patient management.
- Understanding PBL's unique characteristics aids in distinguishing it from other oral cancers.
- Further research into rare NHL subtypes like PBL is warranted for improved outcomes.
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