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Recent development of targeted approaches for the treatment of breast cancer

V L Maruthanila1, R Elancheran1, A B Kunnumakkara2

  • 1Life Sciences Division, Institute of Advanced Study in Science and Technology, Guwahati, Assam, 781035, India.

Breast Cancer (Tokyo, Japan)
|November 1, 2016
PubMed

Insights

This review covers targeted breast cancer therapies and challenges in metastatic breast cancer (MBCa). It explores Hedgehog/Gli 1 signaling pathways for improved treatment strategies and reduced side effects.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Breast cancer is a leading cause of cancer mortality in women globally.
  • Metastatic breast cancer (MBCa) presents significant treatment challenges.
  • Targeted therapies have shown success, with many drugs approved or in clinical trials.

Purpose of the Study:

  • To provide an overview of targeted therapeutic agents for breast cancer.
  • To discuss challenges associated with metastatic breast cancer (MBCa).
  • To explore mechanisms of action, focusing on the Hedgehog/Gli 1 signaling pathway, and future prospects.

Main Methods:

  • Review of existing literature on targeted breast cancer therapies.
  • Analysis of approved drugs and ongoing clinical trials.
  • Examination of signaling pathways involved in breast cancer progression and metastasis.

Main Results:

  • Several targeted drugs (e.g., targeting estrogen receptor, growth factor receptor) are available and in development.
  • Monoclonal antibodies are utilized in breast cancer treatment.
  • Signaling pathways like Notch and Hedgehog/Gli 1 are crucial for understanding bone metastasis.

Conclusions:

  • Advances in understanding tumor biology and signaling pathways are vital for developing new breast cancer treatment strategies.
  • Future strategies should focus on enhancing efficacy and reducing side effects.
  • Targeting pathways such as Hedgehog/Gli 1 offers potential for improved management of metastatic breast cancer.
Keywords:
AngiogenesisBreast cancerEstrogen receptorGrowth factor receptor inhibitorsHedgehog/Gli 1 signalingImmunomodulators

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