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Primary hypothyroidism mimicking pituitary adenoma
The Netherlands Journal of Medicine
|August 1, 1989
Summary
Primary hypothyroidism can cause pituitary enlargement and hyperprolactinaemia in women. Prompt L-thyroxine treatment resolved these pituitary abnormalities, highlighting the importance of thyroid screening.
Area of Science:
- Endocrinology
- Reproductive Medicine
Background:
- Pituitary enlargement and hyperprolactinaemia can mimic pituitary adenomas.
- Secondary amenorrhoea is a potential symptom of hormonal imbalances.
Observation:
- A woman presented with secondary amenorrhoea, mild hyperprolactinaemia, and pituitary enlargement with suprasellar extension.
- Initial presentation mimicked a pituitary adenoma.
Findings:
- The patient was diagnosed with primary hypothyroidism.
- L-thyroxine treatment led to the complete resolution of hyperprolactinaemia and pituitary enlargement.
Implications:
- Thyrotropin determination is crucial in patients with pituitary enlargement and hyperprolactinaemia.
- Undiagnosed primary hypothyroidism should be considered in the differential diagnosis of pituitary abnormalities.
- Hormonal imbalances, particularly thyroid dysfunction, can significantly impact the pituitary gland.