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Adaptive Randomization of Neratinib in Early Breast Cancer

Marc Buyse1, Everardo D Saad1, Tomasz Burzykowski1

  • 1International Drug Development Institute, Louvain-la-Neuve, Belgium marc.buyse@iddi.com.

The New England Journal of Medicine
|November 1, 2016
PubMed
Abstract

No abstract available in PubMed .

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The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
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