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Updated: Mar 12, 2026

Ileectomy-induced Bile Overaccumulation in Mouse Intestine
Published on: August 21, 2017
Amyloidosis: an unusual cause of upper gastrointestinal bleeding
Keith Siau1,2, Amera Elzubeir2, Sheldon C Cooper2
1Department of Gastroenterology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.
Abstract:
We report a rare case of upper gastrointestinal bleeding in a 55-year-old man with monoclonal gammopathy of unknown significance presenting with abdominal pain, weight loss and melaena. Gastroscopy was unremarkable, but melaena persisted, with the development of symptomatic anaemia. While colonoscopy excluded a lower gastrointestinal aetiology, CT revealed jejunitis, confirmed at capsule endoscopy. Histopathological examination of specimens obtained at single balloon enteroscopy revealed an unusual aetiology: small bowel AL-amyloidosis. We review his clinical presentation, radiological, endoscopic and histological findings and review the literature of this unusual condition.
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