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A Fatality Related to the Synthetic Opioid U-47700: Postmortem Concentration Distribution.

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This case report details a fatality involving U-47700, a synthetic opioid. Postmortem toxicology revealed significant U-47700 concentrations, contributing to the accidental death.

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Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry
  • Pharmacology

Background:

  • This report examines the postmortem distribution of U-47700, a potent synthetic opioid, in a fatal overdose case.
  • The decedent had a history of drug abuse and was found deceased with drug paraphernalia indicating insufflation.

Observation:

  • Toxicology analysis confirmed U-47700 in peripheral blood (190 ng/mL), central blood (340 ng/mL), liver (1,700 ng/g), vitreous (170 ng/mL), and urine (360 ng/mL).
  • Other detected substances included alprazolam, doxylamine, and diphenhydramine, alongside ibuprofen and THC metabolite.
  • Gastric contents showed only a trace amount of U-47700.

Findings:

  • Gas chromatography-mass spectrometry (GC-MS) was used for identification and quantification following solid-phase and liquid-liquid extraction techniques.
  • The central blood concentration of U-47700 was significantly higher than the peripheral blood concentration.
  • The combined abuse of U-47700 and alprazolam was identified as the cause of death.

Implications:

  • This case highlights the critical role of comprehensive postmortem toxicology in determining the contribution of synthetic opioids to fatalities.
  • Understanding the distribution patterns of U-47700 in various tissues is crucial for forensic investigations.
  • The findings underscore the dangers of polysubstance abuse involving potent synthetic opioids and benzodiazepines.