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Updated: Mar 12, 2026
05:29
A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening
Published on: October 6, 2014
24.6K
Reconnecting Eye to Brain
Michael C Crair1, Carol A Mason2
1Departments of Neuroscience and Ophthalmology & Visual Science, Yale University, New Haven, Connecticut 06520, and michael.crair@yale.edu cam4@columbia.edu.
Summary
Restoring vision after injury requires overcoming significant barriers to retinal ganglion cell regeneration. This review outlines current knowledge and future directions for visual system neural regeneration.
Area of Science:
- Neuroscience
- Ophthalmology
- Regenerative Medicine
Background:
- Retinal ganglion cells (RGCs) possess regenerative capacity, but functional recovery after injury or degeneration is limited.
- Significant barriers impede the restoration of visual function.
Purpose of the Study:
- To summarize current understanding of factors governing RGC axon guidance and target engagement during regeneration.
- To review the state of neural regeneration research in the visual system.
- To identify knowledge gaps and barriers to progress.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of studies on visual system regeneration.
- Inclusion of insights from other model systems relevant to visual system regeneration.
Main Results:
- Current knowledge on axon guidance and target engagement in regenerating axons is summarized.
- Key barriers to visual system regeneration are highlighted.
- Gaps in understanding and areas for future research are identified.
Conclusions:
- Despite known regenerative capacities, substantial obstacles remain for restoring visual function.
- A comprehensive understanding of RGC regeneration and targeted strategies are needed.
- This review provides a blueprint for advancing visual system regeneration research.
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