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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
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Murine Fecal Isolation and Microbiota Transplantation
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The gut microbiome and hypertension.

Meirav Pevsner-Fischer1, Eran Blacher, Evgeny Tatirovsky

  • 1aDepartment of Immunology, Weizmann Institute of Science, Rehovot bNephrology and Hypertension, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.

Current Opinion in Nephrology and Hypertension
|November 1, 2016
PubMed
Summary
This summary is machine-generated.

The gut microbiota influences health and disease. Alterations in gut microbes (dysbiosis) are linked to hypertension, suggesting microbiome-based diagnostics and therapies.

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Area of Science:

  • Microbiology
  • Human Physiology
  • Medical Science

Background:

  • Mammalian mucosal surfaces host a diverse microbial ecosystem, the microbiota.
  • The gut microbiota, the largest microbial community, impacts physiological traits and disease susceptibility.
  • Metagenomic and metabolomic advancements elucidate the microbiota's role in homeostasis.

Purpose of the Study:

  • To review the link between gut microbiome and hypertension.
  • To explore microbiome-based diagnostic and therapeutic strategies for hypertension management.

Main Methods:

  • Literature review of recent studies on gut microbiota and hypertension.
  • Analysis of metagenomic and metabolomic data related to gut dysbiosis.
  • Discussion of emerging microbiome-related techniques.

Main Results:

  • Gut dysbiosis is associated with multifactorial diseases like obesity, diabetes, and cardiovascular disorders.
  • Emerging evidence links gut dysbiosis to essential hypertension, a global health concern.
  • Hypertension is a major risk factor for severe health complications.

Conclusions:

  • The gut microbiome plays a potential role in hypertension pathogenesis.
  • Microbiome-related techniques offer future prospects for hypertension diagnosis and treatment.