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Updated: Mar 12, 2026
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Published on: March 17, 2023
Serum total IgG and IgG4 levels in thyroid eye disease
1Department of Ophthalmology, California Pacific Medical Center, San Francisco, CA, USA.
Purpose:
To investigate the relationship between immunoglobulin G (IgG)4-related disease (IgG4-RD) and thyroid eye disease (TED) with respect to IgG levels.
Patients And Methods:
A retrospective review of total IgG, IgG subclass, and thyroid stimulating immunoglobulin (TSI) levels in 24 patients with TED.
Results:
Five patients (20.8%) demonstrated serum IgG4 levels consistent with IgG4-RD without any additional systemic disease. Total IgG and IgG subclass levels were found to be an inadequate proxy for TSI elevation.
Conclusion:
There may be a subtype of TED patients with elevated IgG4 in the absence of IgG4-RD systemic findings.
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