Bacteremic Group A Streptococcal Co-Infection in Two Adults with H3N2 Influenza in Japan, 2025-2026: A Case Series

Masafumi Seki1

  • 1Division of Infectious Diseases and Infection Control, Saitama Medical University International Medical Center, Hidaka City, Saitama, Japan.

Insights

Influenza A co-infection with Group A Streptococcus (GAS) can be severe, especially during H3N2 subclade K seasons. Early antiviral treatment, vaccination, and suspicion for invasive GAS in shock patients are crucial for survival.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Public Health

Background:

  • Group A Streptococcus (GAS) bacteremia is a severe complication of influenza.
  • The 2025-2026 influenza season in Japan was dominated by H3N2 subclade K.
  • Co-infections can significantly alter disease severity and outcomes.

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