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Updated: Mar 12, 2026
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
18F-Florbetaben: A New Tool for Amyloidosis Staging?
Emmanuel D'Estanque1, Benjamin Chambert, Olivier Moranne
1From the *Nuclear Medicine Department, and †Nephrology Department, University Hospital, Nîmes; and ‡INSERM U1194, IRCM, Montpellier, France.
Abstract:
We report the case of a 73-year-old man with a documented (renal biopsy) light-chain amyloidosis (AL) imaged with F-AV-1 (F-florbetaben) compared with a volunteer. A cardiac amyloidosis was suspected. As it was an AL and not a transthyretin amyloidosis, F-FDG and F-florbetaben PET/CT were preferred to bone scan. F-FDG scintigraphy showed a focal cardiac hypermetabolism. In addition of the heart, F-florbetaben scintigraphy showed an intense spleen and thyroid pathologic uptake and a moderate salivary gland and kidney uptake. F-florbetaben PET/CT appears to be useful for staging systemic amyloidosis.
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