Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.3K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.3K
Structure and Function of Platelets01:18

Structure and Function of Platelets

4.4K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.4K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.8K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.8K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.7K
Overview
85.7K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

1.4K
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.4K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

17.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
17.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The perineurium integrates leptin with its sympathetic outflow to protect against obesity.

Nature metabolism·2026
Same author

Lymphoid tissue chemokines limit priming duration to preserve CD8<sup>+</sup> T cell functionality.

Science (New York, N.Y.)·2026
Same author

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.

Nature reviews. Immunology·2026
Same author

Abortive infection: T cells as early, antibody-independent defenders.

Nature reviews. Immunology·2026
Same author

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation.

Science (New York, N.Y.)·2026
Same author

Optimising Recovery of Hepatic Regulatory T Cells: A Practical Guide Using ARTC2 Blockade.

European journal of immunology·2025

Related Experiment Video

Updated: Mar 12, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K

Platelet-mediated modulation of adaptive immunity.

Matteo Iannacone1

  • 1Division of Immunology, Transplantation and Infectious Diseases, Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 58, Milan, 20132, Italy.

Seminars in Immunology
|November 3, 2016
PubMed
Summary

Platelets, crucial for blood clotting, also play a significant role in immunity. This review highlights how platelets coordinate adaptive immune responses, particularly in viral hepatitis, with potential clinical implications.

More Related Videos

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

8.2K
An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

880

Related Experiment Videos

Last Updated: Mar 12, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K
A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

8.2K
An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

880

Area of Science:

  • Immunology
  • Hematology
  • Infectious Diseases

Background:

  • Platelets are key hemostasis effectors with diverse mediators and surface receptors involved in inflammation and immunity.
  • Platelet biology suggests an evolutionary link to innate defensive cells, positioning them at the coagulation-immunity interface.
  • Platelet roles in innate immunity are recognized, but their modulation of adaptive immunity is underappreciated.

Purpose of the Study:

  • To review how platelets coordinate adaptive immune responses.
  • To use mouse models of viral hepatitis as a paradigm.
  • To suggest potential clinical implications of platelet-mediated adaptive immunity.

Main Methods:

  • Review of existing literature on platelet function in immunity.
  • Analysis of mouse models of viral hepatitis to illustrate platelet roles.
  • Exploration of the interface between coagulation and adaptive immunity.

Main Results:

  • Platelets possess mediators and receptors integral to inflammatory and immune responses.
  • Platelets are increasingly recognized for direct antimicrobial defense and innate immunity enhancement.
  • Platelet-mediated coordination of adaptive immunity is evident, particularly in viral hepatitis models.

Conclusions:

  • Platelets are multifunctional cells bridging coagulation and immunity.
  • Understanding platelet roles in adaptive immunity is crucial for immunology.
  • Platelet functions in adaptive immunity, exemplified by viral hepatitis, have significant clinical implications.