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Muddled mechanisms: recent progress towards antimalarial target identification.

Rachel L Edwards1, Audrey R Odom John2

  • 1Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

F1000Research
|November 3, 2016
PubMed
Summary
This summary is machine-generated.

Malaria treatment failures are rising due to drug resistance. This review highlights innovative methods for identifying new antimalarial drug targets and mechanisms of action to combat Plasmodium falciparum.

Keywords:
AsiaMalariaPlasmodium falciparumtherapy

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Area of Science:

  • Drug discovery and development
  • Infectious diseases
  • Parasitology

Background:

  • Malaria rates have decreased due to control measures and artemisinin-based combination therapies (ACTs).
  • Emerging resistance to ACTs in Southeast Asia poses a significant threat, potentially leading to widespread treatment failures if it spreads to Africa.
  • Novel antimalarial therapeutics with new mechanisms of action (MOA) are urgently needed to address the growing threat of drug resistance.

Approach:

  • High-throughput screening (HTS) campaigns have identified numerous compounds active against Plasmodium falciparum.
  • Target identification for these hit compounds is challenging, often being labor-intensive and difficult to interpret.
  • This review focuses on innovative approaches for target assignment and elucidation of MOA for antimalarial compounds.

Key Points:

  • Discusses methods instrumental in overcoming challenges in antimalarial target identification.
  • Highlights studies employing novel techniques for elucidating MOA of potential antimalarial drugs.
  • Emphasizes the impact of these target identification strategies on the field of malaria research.

Conclusions:

  • Innovative approaches are crucial for identifying novel antimalarial drug targets and understanding their MOA.
  • Effective target identification is essential for developing new therapeutics to combat drug-resistant malaria.
  • Continued research into novel MOA is vital to stay ahead of evolving Plasmodium falciparum resistance.