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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
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Quorum sensing and microbial drug resistance.
Yu-fan Chen1, Shi-yin Liu1, Zhi-bin Liang1
11. Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; 2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China.
Yi Chuan = Hereditas
|November 4, 2016
Summary
Microbial drug resistance is a growing global threat. This review explores how quorum sensing (microbial cell-cell communication) regulates resistance mechanisms like biofilm formation and efflux pumps, suggesting quorum quenching as a novel control strategy.
Area of Science:
- Microbiology
- Molecular Biology
- Drug Resistance Mechanisms
Background:
- Microbial drug resistance is a significant global health concern.
- Quorum sensing (QS), a cell-density-dependent communication system, regulates various microbial processes.
- Emerging evidence links QS systems to the evolution of microbial drug resistance.
Purpose of the Study:
- To summarize microbial drug resistance mechanisms.
- To review quorum sensing (QS) systems and their role in microbial drug resistance.
- To discuss quorum quenching as a potential strategy to combat antimicrobial resistance.
Main Methods:
- Literature review focusing on microbial drug resistance.
- Analysis of quorum sensing (QS) mechanisms and chemical signaling.
- Examination of QS-mediated regulation of biofilm formation and drug efflux pumps.
Main Results:
- QS systems are intricately linked with microbial drug resistance.
- QS regulates key resistance mechanisms, including biofilm formation and drug efflux.
- High bacterial cell density via QS enhances drug tolerance and pathogenicity.
Conclusions:
- Quorum sensing plays a critical role in the development and maintenance of microbial drug resistance.
- Targeting QS pathways through quorum quenching offers a promising therapeutic strategy.
- Understanding the QS-drug resistance nexus is crucial for developing novel antimicrobial interventions.
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