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Lymphatic Regulation of Cellular Trafficking
1MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS UK.
Journal of Clinical & Cellular Immunology
|October 1, 2014
Summary
Recent advances reveal how immune cells enter lymphatic vessels. This review details leukocyte trafficking, lymphatic vessel ultrastructure, and inflammation
Area of Science:
- Immunology
- Vascular Biology
- Cell Biology
Background:
- Lymphatic vessels are crucial for immune surveillance and regulation.
- Understanding leukocyte entry and migration into lymphatics has been limited.
- Recent discoveries have transformed our knowledge of lymphatic vessel function.
Purpose of the Study:
- To critically review recent literature on leukocyte entry into lymphatic vessels.
- To highlight key discoveries in lymphatic vessel ultrastructure and function.
- To discuss controversies and updates on leukocyte trafficking mechanisms.
Main Methods:
- Microscopic imaging
- Transgenic animal models
- Specific marker development
- Function-blocking monoclonal antibodies (mAbs)
Main Results:
- Detailed ultrastructure of leukocyte entry sites in lymphatic vessels.
- Controversies regarding integrin adhesion, chemotaxis, and haptotaxis in dendritic cell (DC) entry.
- Changes in lymphatic architecture during inflammation and altered leukocyte trafficking.
- Emerging roles for hyaluronan and LYVE-1 in leukocyte transit.
Conclusions:
- Significant progress has been made in understanding leukocyte entry into lymphatic vessels.
- Inflammation profoundly alters lymphatic vessel structure and leukocyte trafficking dynamics.
- Hyaluronan and LYVE-1 are likely key players in leukocyte transit through lymphatics.
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