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Pediatric Anesthetic Management of a Patient With Warburg Micro Syndrome, a Rare Autosomal Recessive Genetic Disorder

Esha Thakkar1, Michael McNally1, Adrienne Hutton2

  • 1Brody School of Medicine at East Carolina University Greenville North Carolina USA.

Clinical Case Reports
|October 13, 2025
PubMed

Insights

Anesthetic management for Warburg micro syndrome, a rare genetic disorder, was successfully achieved in a pediatric patient. Total intravenous anesthesia (TIVA) and incisional Exparel provided a safe approach for this challenging case.

Area of Science:

  • Anesthesiology
  • Genetics
  • Pediatric Medicine

Background:

  • Warburg micro syndrome is an extremely rare autosomal recessive genetic disorder.
  • Limited documented cases (approx. 100 families worldwide) highlight the rarity and potential challenges in patient management.

Purpose of the Study:

  • To describe a safe and successful anesthetic strategy for a pediatric patient diagnosed with Warburg micro syndrome.
  • To evaluate the utility of total intravenous anesthesia (TIVA) and incisional Exparel in this specific patient population.

Main Methods:

  • The study details the anesthetic management of a single pediatric patient with Warburg micro syndrome.
  • Total intravenous anesthesia (TIVA) was employed for general anesthesia.
  • Incisional administration of Exparel was utilized for postoperative pain management.

Main Results:

  • The anesthetic management using TIVA and incisional Exparel was demonstrated to be safe and successful.
  • The patient experienced a positive outcome with effective pain control post-procedure.

Conclusions:

  • Total intravenous anesthesia (TIVA) combined with incisional Exparel represents a viable and safe anesthetic approach for pediatric patients with Warburg micro syndrome.
  • This case report contributes valuable clinical data for managing this exceptionally rare condition.
Keywords:
TIVAWarburg micro syndromecongenital diseaseexparelpharmacologytranexamic acid

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