Safe General Anesthesia in a Pediatric Patient With 1p36.33 Duplication Syndrome: A Rare Case Report

Area of Science:

• Genetics and rare diseases
• Anesthesiology and critical care
• Mitochondrial biology

Background:

• 1p36.33 Duplication Syndrome is an extremely rare autosomal dominant disorder.
• It involves disruption of the ATAD3 gene cluster, crucial for mitochondrial membrane proteins.
• Limited literature exists on characteristic findings, with no data on anesthetic management.

Purpose of the Study:

• To report the anesthetic management of a pediatric patient with 1p36.33 Duplication Syndrome.
• To highlight the successful and uneventful perioperative care in this rare condition.
• To provide preliminary insights into safe anesthetic practices for 1p36.33 Duplication Syndrome.

Main Methods:

• Case report of a pediatric patient with 1p36.33 Duplication Syndrome.
• Detailed description of anesthetic techniques and perioperative management.
• Review of existing literature on the syndrome and anesthetic considerations.

Main Results:

• Successful and uneventful anesthetic care was provided to the pediatric patient.
• No intraoperative or postoperative complications related to the syndrome were observed.
• The case demonstrates the feasibility of safe anesthetic management in this population.

Conclusions:

• Anesthetic management for 1p36.33 Duplication Syndrome is achievable with careful planning.
• This case provides a foundation for developing evidence-based anesthetic guidelines.
• Further research is needed to establish comprehensive anesthetic protocols for this rare disorder.