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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Classification01:23

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

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Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Multi-particulate Systems: Cutting-edge Technology for Controlled Drug Delivery.

Sarika Wairkar1, Ram Gaud, Adhithi Raghavan

  • 1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, V.L.Mehta Road, Vile Parle (W), Mumbai, - 400 056, Maharashtra India.

Recent Patents on Drug Delivery & Formulation
|November 5, 2016
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Advanced multi-particulate dosage forms offer enhanced drug delivery, improving therapeutic efficacy and bioavailability. This review explores patented technologies for these systems, aiding future development in controlled drug release.

Keywords:
Multi-particulate systemscontrolled drug deliverydrug releasepolymers

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Formulation Science

Background:

  • Multi-particulate dosage forms have gained significant attention in the last two decades.
  • They show tremendous potential as drug delivery systems with diverse applications.

Purpose of the Study:

  • To provide an overview of advanced technologies and patents for designing multi-particulate dosage forms.
  • To highlight mechanisms that overcome limitations of conventional oral dosage forms.

Main Methods:

  • Review of recent patented technologies focused on multi-particulate system design.
  • Analysis of technologies enhancing therapeutic efficacy, oral bioavailability, and reducing toxicity.
  • Examination of intellectual property and market opportunities for manufacturers.

Main Results:

  • Overview of advanced technologies and patents based on different design principles.
  • Detailed characteristics and mechanisms of current multi-particulate technologies.
  • Exploration of applications for these advanced dosage forms.

Conclusions:

  • Comprehensive knowledge of these technologies is crucial for further development.
  • Facilitates the creation of platform technologies for multi-particulate controlled drug delivery systems.