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Role of LRRTMs in synapse development and plasticity
Reiko T Roppongi1, Benyamin Karimi1, Tabrez J Siddiqui1
1Department of Physiology and Pathophysiology, College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, 710 William Avenue, Winnipeg R3Y 0Z3, MB, Canada.
Neuroscience Research
|November 7, 2016
Summary
Leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) are key synapse organizers. This review covers their structure, function, and links to psychiatric disorders.
Area of Science:
- Neuroscience
- Synaptic Biology
- Molecular Psychiatry
Background:
- Leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) are crucial for excitatory synapse development and function.
- LRRTMs interact with neurexins and heparan sulfate proteoglycans (HSPGs).
- Genes for LRRTMs, neurexins, and HSPGs are linked to psychiatric disorders.
Purpose of the Study:
- To review the literature on LRRTMs.
- To cover their structural features, expression, evolution, and synaptogenic roles.
- To discuss their involvement in synaptic plasticity and disease associations.
Main Methods:
- Literature review of structural features.
- Analysis of expression patterns in developing and adult brains.
- Examination of evolutionary origins and synaptogenic discovery.
Main Results:
- LRRTMs are essential for organizing excitatory synapses.
- Their expression and function are critical during brain development.
- Dysregulation is implicated in the pathophysiology of psychiatric disorders.
Conclusions:
- LRRTMs are vital synaptic organizers with significant roles in brain development and plasticity.
- Understanding LRRTMs offers insights into the molecular basis of psychiatric disorders.
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