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Complete Genome Sequence of the Neonatal Meningitis-Causing Escherichia coli Strain NMEC O18

Bryon A Nicholson1, Yvonne M Wannemuehler1, Catherine M Logue1

  • 1Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.

Genome Announcements
|November 5, 2016
PubMed

Insights

Neonatal meningitis Escherichia coli (NMEC) causes severe infant illness and death. We sequenced the complete genome of a highly virulent NMEC O18 strain (NMEC 58) to understand its pathogenesis.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Neonatal meningitis Escherichia coli (NMEC) is a significant cause of bacterial meningitis in newborns.
  • NMEC infections lead to high mortality rates and long-term neurological complications in infants.

Purpose of the Study:

  • To present the complete genome sequence of a highly virulent NMEC O18 strain (NMEC 58).
  • To provide genomic data for understanding NMEC virulence and pathogenesis.

Main Methods:

  • Whole-genome sequencing of the NMEC O18 (NMEC 58) strain.
  • Bioinformatic analysis of the obtained genome sequence.

Main Results:

  • The complete genome sequence of NMEC O18 (NMEC 58) was successfully obtained.
  • The strain was characterized as highly virulent, belonging to serotype O18ac:K1 and sequence type ST416.

Conclusions:

  • The availability of this genome sequence facilitates further research into NMEC virulence factors.
  • Understanding the genetic basis of NMEC O18 pathogenicity can aid in developing targeted interventions.

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