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The Interaction Between Niche and Hematopoietic Stem Cells

Chaoyu Wang1, Chen Tian1, Yizhuo Zhang1

  • 1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060 China.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
|November 5, 2016
PubMed

Hematopoietic stem cells (HSCs) are one of the somatic stem cells that have the ability to regenerate the entire blood system in a hierarchical way for the duration of an adult life. HSCs reside in the bone marrow niche which contain different cells and molecules that regulate the balance of HSC dormancy and activation. Here, we describe the interaction between HSCs and their niche, in particularly the involvement of some signaling pathway. Insights into the hematopoietic microenvironment will help to obtain a better understanding of normal hematopoiesis and how environmental factors affect these processes.

Keywords:
HSCsMicroenvironmentSignaling pathway

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