Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fibril-associated Collagen01:11

Fibril-associated Collagen

3.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.5K
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

3.6K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
3.6K
Fibrous Proteins00:55

Fibrous Proteins

5.0K
Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
5.0K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

3.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.7K
Structural Protein Function01:56

Structural Protein Function

30.3K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.3K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

9.9K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
9.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atrial Fibrillation, Cerebral Small Vessel Disease and Gender Medicine: Focus on Biomarkers and Neuroimaging.

Journal of clinical medicine·2026
Same author

A combination of 2 rapid immunoassays significantly improves diagnostic sensitivity for heparin-induced thrombocytopenia.

American journal of clinical pathology·2026
Same author

Marfan Before Marfan? Iconodiagnostic Analysis of a Possible Marfan Spectrum Phenotype in an Etruscan Sculpture.

Clinical genetics·2026
Same author

Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.

Circulation·2026
Same author

Bicuspid Aortic Valve: Old and Novel Gene Contribution to Disease Onset and Complications.

Diagnostics (Basel, Switzerland)·2026
Same author

Measuring Direct Oral Anticoagulant Levels in Laboratory Practice: Impact of Different Storage Conditions of Blood Samples.

International journal of laboratory hematology·2025
Same journal

The predictive power of neuropsychological measures in MCI: early detection of dementia conversion.

Frontiers in aging neuroscience·2026
Same journal

Age-associated neuronal micronuclei formation and transfer to microglia.

Frontiers in aging neuroscience·2026
Same journal

Ershiwuwei Shanhu Pill ameliorates cognitive impairment in Alzheimer's disease mice by remodeling gut microbiota and host serum metabolites.

Frontiers in aging neuroscience·2026
Same journal

Behind the scenes of a 7T MRI clinical study in Alzheimer's disease: challenges and recommendations for future research.

Frontiers in aging neuroscience·2026
Same journal

Striatal functional connectivity alterations in mild cognitive impairment subtypes defined by CSF A/T biomarkers.

Frontiers in aging neuroscience·2026
Same journal

State sensitivity and five-year longitudinal stability of resting-state EEG biomarker candidates in healthy adults.

Frontiers in aging neuroscience·2026
See all related articles

Related Experiment Video

Updated: Mar 12, 2026

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.8K

Fibrillins in Tendon.

Betti Giusti1, Guglielmina Pepe1

  • 1Department of Experimental and Clinical Medicine, Excellence Centre for Research, Transfer and High Education for the Development of De Novo Therapies (DENOTHE), University of FlorenceFlorence, Italy; Marfan Syndrome and Related Disorders Regional (Tuscany) Referral Center, Careggi HospitalFlorence, Italy.

Frontiers in Aging Neuroscience
|November 5, 2016
PubMed
Summary
This summary is machine-generated.

Elastic fibers (EF) in tendons, composed of fibrillin and elastin, are crucial for tendon mechanics. Alterations in EF, particularly fibrillin, are linked to connective tissue disorders like Marfan syndrome.

Keywords:
Marfan syndromecontractureselastic fibersextracellular matrixfibrillinoxytalan fiberstendon

More Related Videos

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction
10:37

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction

Published on: January 16, 2014

6.5K
Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization
12:13

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

Published on: October 28, 2013

11.4K

Related Experiment Videos

Last Updated: Mar 12, 2026

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

1.8K
Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction
10:37

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction

Published on: January 16, 2014

6.5K
Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization
12:13

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

Published on: October 28, 2013

11.4K

Area of Science:

  • Biomaterials Science
  • Connective Tissue Biology
  • Molecular Biology

Background:

  • Tendons, primarily collagen, contain elastic fibers (EF) comprising fibrillin and elastin, making up 1-2% of dry mass.
  • Recent research is exploring the structure and function of EF within tendons.
  • This review focuses on EF organization, fibrillin's role, and associated clinical conditions.

Approach:

  • Literature review of studies on elastic fiber organization in tendons.
  • Analysis of fibrillin structure and function.
  • Correlation of elastic fiber alterations with clinical manifestations in connective tissue disorders.

Key Points:

  • Elastic fibers, though a small component, may significantly influence tendon mechanics.
  • Fibrillin microfibrils are key components of elastic fibers in tendons.
  • Alterations in fibrillin are implicated in joint hypermobility and contractures.

Conclusions:

  • Genetic mutations affecting fibrillin 1 (FBN1) and fibrillin 2 (FBN2) genes cause Marfan syndrome and Beals syndrome, respectively.
  • These syndromes exhibit clinical features such as joint hypermobility and contractures, linked to altered elastic fibers in tendons.