Search research articles

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Amplifying tumour antigen presentations from intratumourally entrapped dendritic cells.

Nature nanotechnology·2026

Same author

Transplanting light-dependent reactions for mammalian eye photosynthesis.

Cell·2026

Same author

Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors.

Cell communication and signaling : CCS·2026

Same author

Heterogeneous Magnetic Resonance Nanoprobe for Assisting Liver Fibrosis Three-Dimensional Reconstruction and Cascaded Therapy.

ACS nano·2026

Same author

Bacteria-responsive DNAgel system for targeted delivery of photothermally enhanced MXene/MoS<sub>2</sub> in the treatment of pyogenic osteomyelitis.

Bioactive materials·2025

Same author

Chiral Gold Staining Enables <i>In Situ</i> Plasmonic Engineering for Single-Bacterium Microscopic Imaging Analysis.

Nano letters·2025

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Mar 12, 2026

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

Published on: December 16, 2013

Reducing ZnO nanoparticles toxicity through silica coating.

Sing Ling Chia¹, David Tai Leong¹

¹Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore.

|November 5, 2016

Summary

Silica coating reduces zinc oxide nanoparticles (ZnO NPs) toxicity by preventing zinc ion release, maintaining antimicrobial properties for food applications. High concentrations still pose risks to gut cells, highlighting the need for safer design.

Keywords:

Inorganic chemistry Materials science Physical chemistry

More Related Videos

Generation of Zerovalent Metal Core Nanoparticles Using n-2-aminoethyl-3-aminosilanetriol

Generation of Zerovalent Metal Core Nanoparticles Using n-2-aminoethyl-3-aminosilanetriol

Published on: February 11, 2016

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

Related Experiment Videos

Last Updated: Mar 12, 2026

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

Published on: December 16, 2013

Generation of Zerovalent Metal Core Nanoparticles Using n-2-aminoethyl-3-aminosilanetriol

Generation of Zerovalent Metal Core Nanoparticles Using n-2-aminoethyl-3-aminosilanetriol

Published on: February 11, 2016

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

Area of Science:

Nanotechnology
Materials Science
Food Science

Background:

Zinc oxide nanoparticles (ZnO NPs) exhibit antimicrobial properties beneficial for food preservation.
High perceived toxicity of ZnO NPs has limited their use as food additives.
Previous toxicity studies did not fully replicate the conditions of ingestion.

Purpose of the Study:

To reduce the toxicity of ZnO NPs through surface modification with silica coating.
To evaluate the behavior and biocompatibility of silica-coated ZnO NPs in simulated digestive fluids.
To assess the impact of silica coating on the antimicrobial activity and cytotoxicity of ZnO NPs.

Main Methods:

Synthesized ZnO NPs and coated them with silica.
Tested NPs in synthetic saliva and gastric juice to mimic digestive conditions.
Exposed coated and uncoated NPs to colorectal cell lines to determine cytotoxicity.
Assessed antimicrobial activity against E. coli and S. aureus.

Main Results:

Silica coating effectively reduced ZnO NP dissolution into zinc ions in both neutral and acidic conditions.
Silica-coated ZnO NPs showed significantly lower cytotoxicity to colorectal cells compared to uncoated ZnO NPs.
Antimicrobial activity against E. coli and S. aureus was preserved after silica coating.
High concentrations of silica-coated ZnO NPs still induced cytotoxicity in mammalian gut cells.

Conclusions:

Silica coating is a viable strategy to enhance the biocompatibility of ZnO NPs for food-related applications.
This approach offers a safer-by-design solution for utilizing ZnO NPs as antimicrobial agents.
Further research is needed to determine safe concentration limits for silica-coated ZnO NPs in food products.