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Updated: Mar 12, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
Time-domain diffuse optical tomography using silicon photomultipliers: feasibility study
Laura Di Sieno1, Judy Zouaoui2, Lionel Hervé2
1Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milano 20133, Italy.
Abstract:
Silicon photomultipliers (SiPMs) have been very recently introduced as the most promising detectors in the field of diffuse optics, in particular due to the inherent low cost and large active area. We also demonstrate the suitability of SiPMs for time-domain diffuse optical tomography (DOT). The study is based on both simulations and experimental measurements. Results clearly show excellent performances in terms of spatial localization of an absorbing perturbation, thus opening the way to the use of SiPMs for DOT, with the possibility to conceive a new generation of low-cost and reliable multichannel tomographic systems.

