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Related Concept Videos

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Related Experiment Video

Updated: Mar 12, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
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Autonomic dysfunction in patients with essential tremor.

Yasin Habipoglu1, Murat Alpua1, Cemil Bilkay2

  • 1Department of Neurology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|November 5, 2016
PubMed
Summary

Essential tremor (ET) patients show impaired autonomic nervous system function, specifically in sympathetic skin response (SSR) tests. These findings suggest sympathetic dysfunction may be a feature of essential tremor.

Keywords:
Autonomic dysfunctionEssential tremorR–R interval variationSympathetic skin response

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Area of Science:

  • Neurology
  • Autonomic Neuroscience
  • Clinical Electrophysiology

Background:

  • Essential tremor (ET) is a common neurological disorder.
  • Autonomic nervous system (ANS) dysfunction has been anecdotally reported in ET patients.
  • Comprehensive evaluation of ANS function in ET is lacking.

Purpose of the Study:

  • To investigate autonomic function in patients diagnosed with essential tremor.
  • To compare autonomic responses between ET patients and healthy controls.
  • To identify potential electrophysiological markers of autonomic dysfunction in ET.

Main Methods:

  • Electrophysiological assessments were conducted on 31 adult ET patients and 26 healthy controls.
  • Autonomic function was evaluated using sympathetic skin response (SSR) and R-R interval variation (RRIV) tests.
  • Statistical analysis compared SSR latency/amplitude and RRIV values between groups.

Main Results:

  • ET patients exhibited significantly delayed SSR latency compared to controls (P=0.01).
  • The mean amplitude of SSR was significantly lower in ET patients versus controls (P=0.001).
  • No significant differences in R-R interval variation (RRIV) were observed between the groups.

Conclusions:

  • Autonomic nervous system dysfunction, particularly sympathetic dysfunction, may be present in patients with essential tremor.
  • Sympathetic skin response (SSR) tests are a sensitive method for detecting autonomic abnormalities in ET.
  • These findings highlight the potential role of SSR in the clinical assessment of essential tremor.