Novel biogenic synthesis of silver nanoparticles and their therapeutic potential

Here, we explored the medicinal uses of the novel biogenic silver nanoparticles of Pterospermum acerifolium (PaAgNPs) as a cost effective, eco-friendly, reducing and stabilizing compounds. The formation of PaAgNPs was confirmed by changing its color from colorless to yellowish brown, with maximum absorbance at 417 nm. FTIR spectrum of PaAgNPs suggested the presence of polycyclic compound similar to betulinic acid which plays as a capping agent and provided stability to PaAgNPs. FESEM and HRTEM images depicted the spherical shape of synthesized biogenic silver nanoparticles with an average particle size range of 10-20 nm. The EDX spectrum of the solution confirmed the presence of elemental silver signals. The crystalline nature of PaAgNPs was identified by XRD technique and its stability was recorded using Zeta potential analyzer. The antioxidant potential was assayed using diphenyl-beta-picrylhydrazyl (DPPH). Maximum free radical scavenging action of PaAgNPs was 69.52% as compared to 63.53% for PALE. Using a model of carrageenan-induced paw edema in rats, PaAgNPs showed two-fold enhanced anti-inflammatory activity in vivo.