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Mouse strain differences in punished ethanol self-administration.

Lindsay R Halladay1, Adrina Kocharian1, Andrew Holmes1

  • 1Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA), NIH, Bethesda, MD, USA.

Alcohol (Fayetteville, N.Y.)
|November 6, 2016
PubMed
Summary
This summary is machine-generated.

Mouse strain differences reveal genetic factors in compulsive alcohol use. Some strains show reduced drinking under punishment, while others, like DBA/2J, persist despite negative consequences, suggesting unique neural pathways for alcohol-use disorders.

Keywords:
AddictionAlcoholAmygdalaHippocampusMousePunishment

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Area of Science:

  • Neuroscience
  • Genetics
  • Behavioral Science

Background:

  • Alcohol-use disorders (AUDs) are complex compulsive behaviors with significant preclinical research focus.
  • Understanding the neural and genetic underpinnings of AUDs is crucial for developing effective treatments.
  • Comparing distinct mouse strains offers a powerful approach to identify genetic contributions to compulsive behaviors.

Purpose of the Study:

  • To investigate strain-specific differences in punished ethanol self-administration in mice.
  • To identify genetic factors contributing to compulsive-like behaviors related to alcohol consumption.
  • To examine the impact of punishment and context on ethanol self-administration across different mouse strains.

Main Methods:

  • Utilized a rodent assay for punished ethanol self-administration in four inbred mouse strains (C57BL/6J, DBA/2J, 129S1/SvImJ, BALB/cJ).
  • Trained mice using an operant task with a sucrose-fading procedure for 10% ethanol self-administration.
  • Administered punishment sessions involving alternating ethanol rewards and footshocks, followed by probe tests to assess behavioral responses.

Main Results:

  • Significant strain differences were observed in both training performance and the attenuation of ethanol self-administration by punishment.
  • 129S1/SvImJ and BALB/cJ strains showed robust suppression of ethanol intake under punishment.
  • C57BL/6J behavior was attenuated only when punishment and probe tests occurred in the same context, while DBA/2J mice remained insensitive to punishment.
  • DBA/2J mice exhibited heightened compulsive-like ethanol self-administration, contrasting with previous findings of ethanol avoidance in this strain.

Conclusions:

  • Mouse strain genetics significantly influence responses to punishment in ethanol self-administration paradigms.
  • DBA/2J mice may display a heightened compulsive-like phenotype for ethanol intake, warranting further investigation into underlying neural mechanisms.
  • These findings provide a foundation for future research into the neural and genetic factors contributing to alcohol-use disorders.