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O-demethylation and N4-acetylation of sulphadimethoxine by the turtle Pseudemys scripta elegans
T B Vree1, J B Vree, N Beneken Kolmer
1Department of Clinical Pharmacy, Sint Radbound Hospital, Nijmegen, The Netherlands.
The Veterinary Quarterly
|July 1, 1989
Abstract:
After an oral dose of 350 mg of sulphadimethoxine, the turtle Pseudemys scripta elegans O-dealkylates sulphadimethoxine at the 2- and 6-position at 38% and 19% respectively, the 2-position being favoured. Acetylation of sulphadimethoxine and its hydroxy metabolites occurs for 57.4%.