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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
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[Muscular metastases from renal cell carcinoma]
Richard Montagnac1, Justine Champion1, Jean Pradel2
1Service de néphrologie hémodialyse, centre hospitalier de Troyes, 101, avenue Anatole-France, 10003 Troyes cedex, France.
Summary
Renal cell carcinoma rarely metastasizes to muscles, even years after nephrectomy. Vigilant follow-up, including limb examination, is crucial for detecting these rare but possible muscle metastases.
Area of Science:
- Oncology
- Medical Imaging
Background:
- Renal cell carcinoma (RCC) is a primary kidney cancer.
- Metastasis is the spread of cancer to other parts of the body.
- Muscle metastasis from RCC is uncommon but documented.
Observation:
- While RCC commonly spreads to lungs, liver, and bone, muscle involvement is rare.
- Muscle metastases can manifest years after initial treatment, such as nephrectomy.
- Standard thoraco-abdomino-pelvic imaging may not always detect metastases in the limbs.
Findings:
- This study emphasizes the importance of considering rare metastatic sites, specifically skeletal muscles.
- Clinical examination and targeted imaging are vital for identifying potential muscle metastases in the limbs.
- Delayed presentation of muscle metastases necessitates long-term surveillance.
Implications:
- Post-nephrectomy follow-up protocols should include thorough physical examination of limbs.
- Clinicians must maintain a high index of suspicion for muscle metastases in RCC survivors.
- Early detection of rare metastases can potentially improve patient outcomes and management strategies.
Keywords:
Carcinomes à cellules rénalesMétastases musculairesRenal cell carcinomaSkeletal muscle metastases
