Related Experiment Video
Updated: Jul 31, 2026
High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors
Published on: March 22, 2011
Hyperferritinemia revealing renal carcinoma with TFE3 gene translocation: a rare case report
Ezékéel Judicaël Bocovo1,2, Yannick Jean Rodrigue Pingdwendé Traoré3, Quentin Caspar2
1Department of Pathology and Cytopathology, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso.
Abstract:
We present the case of a 39-year-old man who was hospitalized due to hyperferritinemia. During the etiological workup, an abdominal-pelvic MRI incidentally revealed a left renal cystic mass classified as Bosniak III. A partial left nephrectomy was performed. Histologically, we observed malignant tumor proliferation with a polymorphic architecture. Immunohistochemistry revealed that the tumor cells weakly expressed keratins (AE1/AE3), but not carbonic anhydrase IX. Due to these unusual findings and the patient's young age, fluorescence in situ hybridization (FISH) was performed, revealing a rearrangement of the TFE3 gene in over 80 % of the tumor cells.
More Related Videos
Related Concept Videos
01:31Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
01:33Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:12Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...