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Biostability of polyurethanes
1Clinic Charlottenburg, Free University Berlin.
Zeitschrift Fur Experimentelle Chirurgie, Transplantation, Und Kunstliche Organe : Organ Der Sektion Experimentelle Chirurgie Der Gesellschaft Fur Chirurgie Der DDR
|January 1, 1989
Summary
Biostability is crucial for prosthetic materials, requiring inertness in biological environments. Standardized testing protocols are needed to ensure polymer safety and clinical approval for medical devices.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Biocompatibility extends beyond medical needs to include material properties crucial for prosthetic device design.
- Prosthetic materials must remain inert in aggressive biological environments, resisting degradation and property changes.
Purpose of the Study:
- To evaluate the biostability of various polyurethanes for prosthetic applications.
- To highlight the need for standardized testing protocols for polymer biostability.
Main Methods:
- In-vitro and in-vivo evaluations of polyurethane materials and fabricated devices (e.g., blood pumps, heart valves).
- Assessment of material properties including mechanical, physical, and chemical characteristics.
Main Results:
- Polyurethanes were evaluated for their inertness, surface integrity, and resistance to degradation in biological settings.
- Results indicated variability in performance, underscoring the need for consistent evaluation methods.
Conclusions:
- Standardized test protocols with well-defined in-vitro and in-vivo methods are essential for proving polymer biostability.
- Establishing a robust data foundation is critical for the clinical approval of biomaterials used in medical devices.