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Marijuana use in acute coronary syndromes
Eman I Draz1, Mervat M Oreby1, Eman A Elsheikh2
1a Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine , Tanta University , Egypt.
The American Journal of Drug and Alcohol Abuse
|November 8, 2016
Summary
Cannabis use may be a risk factor for acute coronary heart disease in young men. This study found significant cardiac changes in cannabis-exposed patients compared to non-exposed individuals.
Area of Science:
- Cardiology
- Toxicology
- Public Health
Background:
- Cannabis is a widely used illicit substance globally.
- Egypt shows a high prevalence of cannabis use among drug users.
Purpose of the Study:
- To determine if cannabis use is a risk factor for acute coronary heart disease in young, low-risk males.
- To compare cardiac pathology in cannabis-exposed versus non-exposed ischemic patients.
Main Methods:
- A cross-sectional study of 138 male patients (≤ 40 years) with acute myocardial infarction.
- Toxicological analysis of urine samples to identify substance use.
- Patients categorized into cannabis-positive, other substance-positive, and substance-negative groups.
Main Results:
- Cannabis-positive patients (group 1) showed a higher incidence of ST-segment elevation myocardial infarction (STEMI) compared to the substance-negative group (group 3).
- Ischemic wall motion abnormalities and abnormal coronary arteries were more prevalent in the cannabis-positive group.
- Significant echocardiographic and angiographic differences were noted between cannabis users and non-users.
Conclusions:
- Cannabis smoking may be a contributing risk factor for cardiac ischemia.
- Further research is warranted to understand the cardiovascular implications of cannabis use.
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