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Helicobacter pylori Infection in Children With Cerebral Palsy: A Cross-Sectional Study
Sally M Ismael1, Dina S Atia1, Salwa A Atlam1
1Faculty of Medicine, Pediatric Department, Tanta University Hospital, Tanta, Egypt.
Pediatric Neurology
|May 24, 2024
Summary
Helicobacter pylori infection is common in children with cerebral palsy (CP). Risk factors include intellectual disability and poor eating ability, leading to more gastrointestinal issues.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Gastroenterology
Background:
- Children with cerebral palsy (CP) often experience co-occurring conditions, including gastrointestinal problems.
- Helicobacter pylori (H. pylori) infection is a prevalent global issue linked to various gastrointestinal symptoms.
Purpose of the Study:
- To determine the prevalence of H. pylori infection in pediatric patients diagnosed with cerebral palsy.
- To identify risk factors and associated gastrointestinal manifestations of H. pylori in children with CP.
Main Methods:
- A cross-sectional study involving 100 children (aged 2-17 years) with CP was conducted over eight months.
- H. pylori stool antigen was detected using enzyme-linked immunosorbent assay (ELISA).
Main Results:
- The prevalence of H. pylori infection was 45% among the studied children with CP.
- Intellectual disability, low socioeconomic status, semisolid diet, and severe eating/drinking difficulties (EDACS levels 4-5) were significant predictors of H. pylori infection.
- H. pylori-positive children with CP exhibited higher incidences of vomiting, abdominal pain, and gastrointestinal bleeding.
Conclusions:
- H. pylori infection is a common comorbidity in children with cerebral palsy.
- Key risk factors for H. pylori infection in this population include intellectual disability, low socioeconomic status, and impaired oral intake.
- H. pylori infection exacerbates gastrointestinal problems in children with CP.
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