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Related Experiment Video

Updated: Mar 12, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

RETINAL VASCULITIS ASSOCIATED WITH NEUROMYELITIS OPTICA.

Mikel Mikhail¹, Ayesha Khan

¹Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.

Retinal Cases & Brief Reports

|November 8, 2016

Summary

Retinal vasculitis, a rare finding, was observed in a patient with neuromyelitis optica (NMO). This case highlights a potential new association between NMO spectrum disorder and ocular inflammation.

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Last Updated: Mar 12, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

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Published on: August 21, 2017

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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Area of Science:

Ophthalmology
Neurology
Immunology

Background:

Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune disease primarily affecting the optic nerves and spinal cord.
Ocular manifestations in NMOSD are common, but retinal vasculitis is not a widely recognized feature.

Observation:

A patient with NMOSD, confirmed by transverse myelitis and positive anti-aquaporin-4 antibodies, presented with neurological symptoms but no initial visual complaints.
Ophthalmological examination revealed active retinal vasculitis in the affected patient.

Findings:

This case represents the first documented instance of retinal vasculitis in a patient diagnosed with neuromyelitis optica or NMOSD.
Diagnostic imaging, including MRI, fluorescein angiography, and OCT, supported the findings.

Implications:

The presence of retinal vasculitis may indicate a broader spectrum of ocular involvement in NMOSD.
This finding warrants further investigation into the relationship between autoimmune neurological disorders and retinal vascular inflammation.